The Wiley Protocol is distinguished from other protocols because it is biomimetic. This term is used to describe the HRT because it denotes a compound that mimics a biological material in its structure and function.

Research done by T. S. Wiley shows that it may not, in fact, just be the molecule that matters. The way the hormone molecule is received at the receptor site and the way receptors are provoked may be at least as important, if not more. The WHI proved that dosing synthetic HRT in a static, low-dose regimen was harmful to woman over 65, particularly in regard to stroke and cardiac events.

The Wiley Protocol is based on the premise that “bio-identical” hormones can only be truly accurately bio-identical if the hormones for replacement mimic, not only those found in the body, but mimic the natural biological process as well. In other words, natural plant derived hormones can accurately be termed bio-identical only when they are dosed in a biomimetic fashion – which must include the natural rhythm.

Biomimetic hormones, the scientifically accurate term, are derived from plant sources and mimic the natural undulating or wavelike rhythms of the hormone blood levels in a normal menstrual cycle of a healthy young woman. It is this natural rhythm that is missing from all other bio-identical and synthetic hormone replacement therapies. It is the absence of this natural rhythm, according to T.S. Wiley, which is responsible for the vast side-effects in both camps.

Our bodies have a rhythm and so do our menstrual cycles. All living beings are regulated by biological cycles.  These cycles have a rhythm and are commonly called circadian rhythms or the circadian clock (Latin: circa=about and dies=day.) This ‘clock’ in our cells measures the rhythm of a 24 hour spin of the planet. For 28 days the moon tracks the repeat of that cycle – and so does the body.

The Wiley Protocol uses this natural rhythm of nature to establish the proper doses of estradiol and natural progesterone that mimic the natural hormones produced by your body. Wiley Protocol is multi-phasic rhythmic dosing, meaning that the topical creams and their amounts vary throughout the 28 day cycle to restore the hormone levels of a woman in her prime.

It is this natural, wave-like rhythm of the hormone blood levels in a normal menstrual cycle of a healthy young woman that is missing from all other bio-identical and synthetic hormone replacement therapies.This approach may open the door for a new look at the possible decline or disappearance of the symptoms and disease states associated with menopause and aging.